Current treatments for biofilm-associated periprosthetic joint infection and new potential strategies.

ABSTRACT: Periprosthetic joint infection (PJI) remains a devastating complication after total joint arthroplasty. Bacteria involved in these infections are notorious for adhering to foreign implanted surfaces and generating a biofilm matrix. These biofilms protect the bacteria from antibiotic treatment and the immune system making eradication difficult. Current treatment strategies including debridement, antibiotics, and implant retention, and one- and two-stage revisions still present a relatively high overall failure rate. One of the main shortcomings that has been associated with this high failure rate is the lack of a robust approach to treating bacterial biofilm. Therefore, in this review, we will highlight new strategies that have the potential to combat PJI by targeting biofilm integrity, the

SUBMITTER: Visperas A 

PROVIDER: S-EPMC9322555 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature