Association of Sequential Organ Failure Assessment (SOFA) components with mortality.

ABSTRACT:

Background

Sequential Organ Failure Assessment (SOFA) is a practical method to describe and quantify the presence and severity of organ system dysfunctions and failures. Some proposals suggest that SOFA could be employed as an endpoint in trials. To justify this, all SOFA component scores should reflect organ dysfunctions of comparable severity. We aimed to investigate whether the associations of different SOFA components with in-hospital mortality are comparable.

Methods

We performed a study based on nationwide register data on adult patients admitted to 26 Finnish intensive care units (ICUs) during 2012-2015. We determined the SOFA score as the maximum score in the first 24 hours after ICU admission. We defined organ failure (OF) as an organ-specific SOFA score of three or

SUBMITTER: Polkki A 

PROVIDER: S-EPMC9322581 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature