Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling.

ABSTRACT: Acute kidney injury (AKI) is a common complication of severe human diseases, resulting in increased morbidity and mortality as well as unfavorable long-term outcomes. Although the mammalian kidney is endowed with an amazing capacity to recover from AKI, little progress has been made in recent decades to facilitate recovery from AKI. To elucidate the early repair mechanisms after AKI, we employed the zebrafish pronephros injury model. Since damaged cells release large amounts of ATP and ATP-degradation products to signal apoptosis or necrosis to neighboring cells, we examined how depletion of purinergic and adenosine receptors impacts the directed cell migration that ensues immediately after a laser-induced tubular injury. We found that depletion of the zebrafish adenosine receptors ador

SUBMITTER: Gessler S 

PROVIDER: S-EPMC9322613 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature