Enantioselective Cytotoxicity of Chiral Diphosphine Ruthenium(II) Complexes Against Cancer Cells.

ABSTRACT: The chiral cationic complex [Ru(η¹ -OAc)(CO)((R,R)-Skewphos)(phen)]OAc (2^R ), isolated from reaction of [Ru(η¹ -OAc)(η² -OAc)(R,R)-Skewphos)(CO)] (1^R ) with phen, reacts with NaOPiv and KSAc affording [RuX(CO)((R,R)-Skewphos)(phen)]Y (X=Y=OPiv 3^R ; X=SAc, Y=OAc 4^R ). The corresponding enantiomers 2^S -4^S have been obtained from 1^S containing (S,S)-Skewphos. Reaction of 2^R and 2^S with (S)-cysteine and NaPF₆ at pH=9 gives the diastereoisomers [Ru((S)-Cys)(CO)(PP)(phen)]PF₆ (PP=(R,R)-Skewphos 2^R -Cys; (S,S)-Skewphos 2^S -Cys). The DFT energetic profile for 2^R with (S)-cysteine in H₂ O indicates that

SUBMITTER: Lovison D 

PROVIDER: S-EPMC9322675 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature