Effective Infection with Dengue Virus in Experimental Neonate and Adult Mice through the Intranasal Route.

ABSTRACT: Dengue virus, the causative agent of dengue fever, life-threatening hemorrhagic fever, and shock syndrome, is mainly transmitted to humans through mosquito vectors. It can also be transmitted through atypical routes, including needle stick injury, vertical transmission, blood transfusion, and organ transplantation. In addition, sporadic cases which have no clear infectious causes have raised the respiratory exposure concerns, and the risks remain unclear. Here, we analyze the respiratory infectivity of the dengue virus in BALB/c suckling and adult immunodeficient mice by the intranasal inoculation of dengue virus serotype 2. The infected mice presented with clinical symptoms, including excitement, emaciation, malaise, and death. Viremia was detected for 3 days post inoculation. Histopathol

SUBMITTER: Qiu M 

PROVIDER: S-EPMC9322762 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature