The β₂-Subunit (AMOG) of Human Na⁺, K⁺-ATPase Is a Homophilic Adhesion Molecule.

ABSTRACT: The β₂ subunit of Na⁺, K⁺-ATPase was originally identified as the adhesion molecule on glia (AMOG) that mediates the adhesion of astrocytes to neurons in the central nervous system and that is implicated in the regulation of neurite outgrowth and neuronal migration. While β₁ isoform have been shown to trans-interact in a species-specific mode with the β₁ subunit on the epithelial neighboring cell, the β₂ subunit has been shown to act as a recognition molecule on the glia. Nevertheless, none of the works have identified the binding partner of β₂ or described its adhesion mechanism. Until now, the interactions pronounced for β₂/AMOG are heterophilic cis-interactions. In the present report we designed expe

SUBMITTER: Roldan ML 

PROVIDER: S-EPMC9322774 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature