Oxidative Glucose Metabolism Promotes Senescence in Vascular Endothelial Cells.

ABSTRACT: Vascular aging is based on the development of endothelial dysfunction, which is thought to be promoted by senescent cells accumulating in aged tissues and is possibly affected by their environment via inflammatory mediators and oxidative stress. Senescence appears to be closely interlinked with changes in cell metabolism. Here, we describe an upregulation of both glycolytic and oxidative glucose metabolism in replicative senescent endothelial cells compared to young endothelial cells by employing metabolic profiling and glucose flux measurements and by analyzing the expression of key metabolic enzymes. Senescent cells exhibit higher glycolytic activity and lactate production together with an enhanced expression of lactate dehydrogenase A as well as increases in tricarboxylic acid cycle act

SUBMITTER: Stabenow LK 

PROVIDER: S-EPMC9322806 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature