Genes of the Glutamatergic System and Tardive Dyskinesia in Patients with Schizophrenia.

ABSTRACT:

Background

Tardive dyskinesia (TD) is an extrapyramidal side effect of the long-term use of antipsychotics. In the present study, the role of glutamatergic system genes in the pathogenesis of total TD, as well as two phenotypic forms, orofacial TD and limb-truncal TD, was studied.

Methods

A set of 46 SNPs of the glutamatergic system genes (GRIN2A, GRIN2B, GRIK4, GRM3, GRM7, GRM8, SLC1A2, SLC1A3, SLC17A7) was studied in a population of 704 Caucasian patients with schizophrenia. Genotyping was performed using the MassARRAY Analyzer 4 (Agena Bioscience™). Logistic regression analysis was performed to test for the association of TD with the SNPs while adjusting for confounders.

Results

No statistically signifi

SUBMITTER: Fedorenko OY 

PROVIDER: S-EPMC9322868 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature