Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors.

ABSTRACT: Tuberculosis (TB) is the oldest human infection disease. Mortality from TB significantly decreased in the 20th century, because of vaccination and the widespread use of antibiotics. However, about a third of the world's population is currently infected with Mycobacterium tuberculosis (Mtb) and the death rate from TB is about 1.4-2 million people per year. In the second half of the 20th century, new extensively multidrug-resistant strains of Mtb were identified, which are steadily increasing among TB patients. Therefore, there is an urgent need to develop new anti-TB drugs, which remains one of the priorities of pharmacology and medicinal chemistry. The antimycobacterial activity of nucleoside derivatives and analogues was revealed not so long ago, and a lot of studies

SUBMITTER: Alexandrova LA 

PROVIDER: S-EPMC9322969 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature