A CD4⁺ T cell reference map delineates subtype-specific adaptation during acute and chronic viral infections.

ABSTRACT: CD4⁺ T cells are critical orchestrators of immune responses against a large variety of pathogens, including viruses. While multiple CD4⁺ T cell subtypes and their key transcriptional regulators have been identified, there is a lack of consistent definition for CD4⁺ T cell transcriptional states. In addition, the progressive changes affecting CD4⁺ T cell subtypes during and after immune responses remain poorly defined. Using single-cell transcriptomics, we characterized the diversity of CD4⁺ T cells responding to self-resolving and chronic viral infections in mice. We built a comprehensive map of virus-specific CD4⁺ T cells and their evolution over time, and identified six major cell states consistently observed in acute and

SUBMITTER: Andreatta M 

PROVIDER: S-EPMC9323004 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature