Going the Extra Mile: Why Clinical Research in Cystic Fibrosis Must Include Children.

ABSTRACT: This is an exciting time for research and novel drug development in cystic fibrosis. However, rarely has the adage, "Children are not just little adults" been more relevant. This article is divided into two main sections. In the first, we explore why it is important to involve children in research. We discuss the potential benefits of understanding a disease and its treatment in children, and we highlight that children have the same legal and ethical right to evidence-based therapy as adults. Additionally, we discuss why extrapolation from adults may be inappropriate, for example, medication pharmacokinetics may be different in children, and there may be unpredictable adverse effects. In the second part, we discuss how to involve children and their families in research. We outline the impo

SUBMITTER: Dobra R 

PROVIDER: S-EPMC9323167 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature