NK Cell-Based Immunotherapy in Colorectal Cancer.

ABSTRACT: Human Natural Killer (NK) cells are all round players in immunity thanks to their powerful and immediate response against transformed cells and the ability to modulate the subsequent adaptive immune response. The potential of immunotherapies based on NK cell involvement has been initially revealed in the hematological setting but has inspired the design of different immune tools to also be applied against solid tumors, including colorectal cancer (CRC). Indeed, despite cancer prevention screening plans, surgery, and chemotherapy strategies, CRC is one of the most widespread cancers and with the highest mortality rate. Therefore, further efficient and complementary immune-based therapies are in urgent need. In this review, we gathered the most recent advances in NK cell-based immunotherapie

SUBMITTER: Della Chiesa M 

PROVIDER: S-EPMC9323201 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature