Clinical and genomic signatures of SARS-CoV-2 Delta breakthrough infections in New York.

ABSTRACT:

Background

In 2021, Delta became the predominant SARS-CoV-2 variant worldwide. While vaccines have effectively prevented COVID-19 hospitalization and death, vaccine breakthrough infections increasingly occurred. The precise role of clinical and genomic determinants in Delta infections is not known, and whether they contributed to increased rates of breakthrough infections compared to unvaccinated controls.

Methods

We studied SARS-CoV-2 variant distribution, dynamics, and adaptive selection over time in relation to vaccine status, phylogenetic relatedness of viruses, full genome mutation profiles, and associated clinical and demographic parameters.

Findings

We show a steep and near-complete replacement of circulating variants with Delta between May and August 2021 in m

SUBMITTER: Duerr R 

PROVIDER: S-EPMC9323230 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature