The Current Knowledge on Clostridioides difficile Infection in Patients with Inflammatory Bowel Diseases.

ABSTRACT: Clostridioides difficile (C. difficile) represents a major health burden with substantial economic and clinical impact. Patients with inflammatory bowel diseases (IBD) were identified as a risk category for Clostridioides difficile infection (CDI). In addition to traditional risk factors for C. difficile acquisition, IBD-specific risk factors such as immunosuppression, severity and extension of the inflammatory disease were identified. C. difficile virulence factors, represented by both toxins A and B, induce the damage of the intestinal mucosa and vascular changes, and promote the inflammatory host response. Given the potential life-threatening complications, early diagnostic and therapeutic interventions are required. The screening for CDI is recommende

SUBMITTER: Boeriu A 

PROVIDER: S-EPMC9323231 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature