Evaluation of Anthelmintic and Anti-Inflammatory Activity of 1,2,4-Triazole Derivatives.

ABSTRACT: Parasitic diseases, caused by intestinal helminths, remain a very serious problem in both human and veterinary medicine. While searching for new nematicides we examined a series of 1,2,4-triazole derivatives 9-22, obtained during reactions of N³-substituted amidrazones with itaconic anhydride. Two groups of compounds, 9-16 and 17-22, differed in the position of the double bond on the methacrylic acid moiety. The toxicity of derivatives 9-22 and the anti-inflammatory activity of 12 and 19-22 were studied on peripheral blood mononuclear cells (PBMC). Antiproliferative activity of compounds 12 and 19-22 was tested cytometrically in PBMC cultures stimulated by phytohemagglutinin.

SUBMITTER: Paprocka R 

PROVIDER: S-EPMC9323247 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature