Brain morphometry and connectivity differs between adolescent- and adult-onset major depressive disorder.

ABSTRACT:

Background

Early-onset (EO) major depressive disorder (MDD) patients experience more depressive episodes and an increased risk of relapse. Thus, on a neurobiological level, adult EO patients might display brain structure and function different from adult-onset (AO) patients.

Methods

A total of 103 patients (66 females) underwent magnetic resonance imaging. Structural measures of gray matter volume (GMV) and functional connectivity networks during resting state were compared between EO (≤19 years) and AO groups. Four residual major depression symptoms, mood, anxiety, insomnia, and somatic symptoms, were correlated with GMV between groups.

Results

We found comparatively increased GMV in the EO group, namely the medial prefrontal and insular cortex, as well as the anteri

SUBMITTER: Blank TS 

PROVIDER: S-EPMC9323432 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature