Alpha-Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction.

ABSTRACT:

Background

The neuronal protein alpha-synuclein (α-Syn) is crucially involved in Parkinson's disease pathophysiology. Intriguingly, torsinA (TA), the protein causative of DYT1 dystonia, has been found to accumulate in Lewy bodies and to interact with α-Syn. Both proteins act as molecular chaperones and control synaptic machinery. Despite such evidence, the role of α-Syn in dystonia has never been investigated.

Objective

We explored whether α-Syn and N-ethylmaleimide sensitive fusion attachment protein receptor proteins (SNAREs), that are known to be modulated by α-Syn, may be involved in DYT1 dystonia synaptic dysfunction.

Methods

We used electrophysiological and biochemical techniques to study synaptic alterations in the dorsal striatum of the Tor1a⁺ /

SUBMITTER: Ponterio G 

PROVIDER: S-EPMC9323501 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature