Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation.

ABSTRACT: Recent genome-wide association studies uncovered part of blood pressure's heritability. However, there is still a vast gap between genetics and biology that needs to be bridged. Here, we followed up blood pressure genome-wide summary statistics of over 750,000 individuals, leveraging comprehensive epigenomic and transcriptomic data from blood with a follow-up in cardiovascular tissues to prioritise likely causal genes and underlying blood pressure mechanisms. We first prioritised genes based on coding consequences, multilayer molecular associations, blood pressure-associated expression levels, and coregulation evidence. Next, we followed up the prioritised genes in multilayer studies of genomics, epigenomics, and transcriptomics, functional enrichment, and their potential suitability as dr

SUBMITTER: Kamali Z 

PROVIDER: S-EPMC9323755 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature