Doxorubicin-Loaded Core-Shell UiO-66@SiO₂ Metal-Organic Frameworks for Targeted Cellular Uptake and Cancer Treatment.

ABSTRACT: Beneficial features of biocompatible high-capacity UiO-66 nanoparticles, mesoporous SiO₂, and folate-conjugated pluronic F127 were combined to prepare the core-shell UiO-66@SiO₂/F127-FA drug delivery carrier for targeted cellular uptake in cancer treatment. UiO-66 and UiO-66-NH₂ nanoparticles with a narrow size and shape distribution were used to form a series of core-shell MOF@SiO₂ structures. The duration of silanization was varied to change the thickness of the SiO₂ shell, revealing a nonlinear dependence that was attributed to silicon penetration into the porous MOF structure. Doxorubicin encapsulation showed a similar final loading of 5.6 wt % for both uncoated and silica-coated particles, demonstrating the potential of the nanoco

SUBMITTER: Trushina DB 

PROVIDER: S-EPMC9324125 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature