Design, fabrication, and characterization of a multimodal reconfigurable bioreactor for bone tissue engineering.

ABSTRACT: In the past decades, bone tissue engineering developed and exploited many typologies of bioreactors, which, besides providing proper culture conditions, aimed at integrating those bio-physical stimulations that cells experience in vivo, to promote osteogenic differentiation. Nevertheless, the highly challenging combination and deployment of many stimulation systems into a single bioreactor led to the generation of several unimodal bioreactors, investigating one or at mostly two of the required biophysical stimuli. These systems miss the physiological mimicry of bone cells environment, and often produced contrasting results, thus making the knowledge of bone mechanotransduction fragmented and often inconsistent. To overcome this issue, in this study we developed a perfusion and electroactiv

SUBMITTER: Montorsi M 

PROVIDER: S-EPMC9324218 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature