Real-time imaging of respiratory effects on cerebrospinal fluid flow in small diameter passageways.

ABSTRACT:

Purpose

Respiration-related CSF flow through the cerebral aqueduct may be useful for elucidating physiology and pathophysiology of the glymphatic system, which has been proposed as a mechanism of brain waste clearance. Therefore, we aimed to (1) develop a real-time (CSF) flow imaging method with high spatial and sufficient temporal resolution to capture respiratory effects, (2) validate the method in a phantom setup and numerical simulations, and (3) apply the method in vivo and quantify its repeatability and correlation with different respiratory conditions.

Methods

A golden-angle radial flow sequence (reconstructed temporal resolution 168 ms, spatial resolution 0.6 mm) was implemented on a 7T MRI scanner and reconstructed using compressed sensing. A phantom setup mimicked

SUBMITTER: Toger J 

PROVIDER: S-EPMC9324219 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature