Signatures of selection in core and accessory genomes indicate different ecological drivers of diversification among Bacillus cereus clades.

ABSTRACT: Bacterial clades are often ecologically distinct, despite extensive horizontal gene transfer (HGT). How selection works on different parts of bacterial pan-genomes to drive and maintain the emergence of clades is unclear. Focusing on the three largest clades in the diverse and well-studied Bacillus cereus sensu lato group, we identified clade-specific core genes (present in all clade members) and then used clade-specific allelic diversity to identify genes under purifying and diversifying selection. Clade-specific accessory genes (present in a subset of strains within a clade) were characterized as being under selection using presence/absence in specific clades. Gene ontology analyses of genes under selection revealed that different gene functions were enriched in different clades. Further

SUBMITTER: White H 

PROVIDER: S-EPMC9324797 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature