Defining changes in physical limitation from the patient perspective: insights from the VITALITY-HFpEF randomized trial.

ABSTRACT:

Aims

Clinically important thresholds in patient-reported outcomes measures like the Kansas City Cardiomyopathy Questionnaire (KCCQ) have not been defined for patients with heart failure and preserved ejection fraction (HFpEF). The aim of this study was to estimate meaningful thresholds for improvement or worsening in the KCCQ physical limitation score (PLS) in patients with HFpEF.

Methods and results

In this pre-specified analysis from VITALITY-HFpEF, anchor- and distribution-based approaches were used to estimate thresholds for improvement or worsening in the KCCQ-PLS using Patient Global Impression of Change (PGIC) as an anchor. The KCCQ-PLS contains six elements, with each increment in response resulting in a change of 4.17 points when converted to a 0-100 scale. The mean

SUBMITTER: Butler J 

PROVIDER: S-EPMC9324829 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature