A multivariant recall-by-genotype study of the metabolomic signature of BMI.

ABSTRACT:

Objective

This study estimated the effect of BMI on circulating metabolites in young adults using a recall-by-genotype study design.

Methods

A recall-by-genotype study was implemented in the Avon Longitudinal Study of Parents and Children. Samples from 756 participants were selected for untargeted metabolomics analysis based on low versus high genetic liability for higher BMI defined by a genetic risk score (GRS). Regression analyses were performed to investigate associations between BMI GRS group and relative abundance of 973 metabolites.

Results

After correction for multiple testing, 29 metabolites were associated with BMI GRS group. Bilirubin was among the most strongly associated metabolites, with reduced levels measured in individuals in the high-BMI GRS group (β

SUBMITTER: Fang S 

PROVIDER: S-EPMC9324973 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature