The Role of Citrate Homeostasis in Merkel Cell Carcinoma Pathogenesis.

ABSTRACT: Merkel cell carcinoma (MCC) is a rare but highly aggressive tumor of the skin with a poor prognosis. The factors driving this cancer must be better understood in order to discover novel targets for more effective therapies. In the search for targets, we followed our interest in citrate as a central and critical metabolite linked to fatty acid synthesis in cancer development. A key to citrate uptake in cancer cells is the high expression of the plasma membrane citrate transporter (pmCiC), which is upregulated in the different adenocarcinoma types tested so far. In this study, we show that the pmCiC is also highly expressed in Merkel cell carcinoma cell lines by western blot and human tissues by immunohistochemistry staining. In the presence of extracellular citrate, MCC cells show an increa

SUBMITTER: Drexler K 

PROVIDER: S-EPMC9325124 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature