Gut Microbiota Characteristics of People with Obesity by Meta-Analysis of Existing Datasets.

ABSTRACT: Obesity is a complex chronic, relapsing, progressive disease. Association studies have linked microbiome alterations with obesity and overweight. However, the results are not always consistent. An integrated analysis of 4282 fecal samples (2236 control (normal weight) group, 1152 overweight, and 894 simple obesity) was performed to identify obesity-associated microbial markers. Based on a random effects model and a fixed effects model, we calculated the odds ratios of the metrics, including bacterial alpha-diversity, beta-diversity, Bacteroidetes/Firmicutes ratio, common genera, and common pathways, between the simple obesity and control groups as well as the overweight and control groups. The random forest model was trained based on a single dataset at the genus level. Feature selection b

SUBMITTER: Gong J 

PROVIDER: S-EPMC9325184 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature