In Vitro and In Silico Investigation of Diterpenoid Alkaloids Isolated from Delphinium chitralense.

ABSTRACT: This study reports the isolation of three new C₂₀ diterpenoid alkaloids, Chitralinine A-C (1-3) from the aerial parts of Delphinium chitralense. Their structures were established on the basis of latest spectral techniques and single crystal X-rays crystallographic studies of chitralinine A described basic skeleton of these compounds. All the isolated Compounds (1-3) showed strong, competitive type inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in comparison to standard allanzanthane and galanthamine however, chitralinine-C remained the most potent with IC₅₀ value of 11.64 ± 0.08 μM against AChE, and 24.31 ± 0.33 μM against BChE, respectively. The molecular docking reflected a binding free energy of -1

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC9325274 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature