The Investigation of HBV Pre-S/S Gene Mutations in Occult HBV Infected Blood Donors with anti-HBs Positive.

ABSTRACT:

Introduction

The coexistence of hepatitis B virus (HBV) and hepatitis B surface antibodies (anti-HBs) in occult hepatitis B virus infection (OBI) is a contradictory phenomenon, and the underlying mechanism is not fully understood. The characteristics of pre-S/S mutations in OBI genotypes B and C (OBI_B and OBI_C) in the presence or absence of anti-HBs were analyzed extensively in this study. Methodology. The amino acid substitutions of envelope proteins of 21 OBI strains, including 4 HBs (+) OBI_B, 6 HBs (-) OBI_B, 6 HBs (+) OBIc, and 5 HBs (-) OBI_C samples, were analyzed and fully compared among groups of HBV genotypes and the presence of anti-HBs.

Results

The mutation rates in pre-S1, pre-S2, and S proteins of OBI

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9325327 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature