Incidence, predictors of success and outcome of LISA in very preterm infants.

ABSTRACT:

Objectives

The aim of this study was to examine the success rate of less invasive surfactant administration (LISA), to identify early predictive factors for the outcome of LISA, and to compare neonatal outcomes between the LISA failure group and the group of infants who were successfully treated with LISA.

Design

A retrospective cohort study.

Patients

Infants born at less than 33 weeks of gestation (n = 158) and treated with LISA for respiratory distress syndrome.

Results

LISA was successful in 86 cases (54.4%); 72 preterm infants (45.6%) needed additional surfactant therapy and/or mechanical ventilation in the first 72 h (LISA failure). In a multivariate logistic regression analysis, six independent predictors of LISA success were identified: core temperature

SUBMITTER: Balazs G 

PROVIDER: S-EPMC9325361 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature