Psychiatric disorders and risk of subsequent dementia: Systematic review and meta-analysis of longitudinal studies.

ABSTRACT:

Objectives

Although psychiatric disorders have been found to be associated with increased risk of dementia, previous findings are mixed, and the nature of these relationships remains poorly understood. We examined longitudinal associations between depression, anxiety, post-traumatic stress disorders (PTSD), bipolar disorder (BPD), psychotic disorders and subsequent dementia.

Methods

We searched three databases for longitudinal, population-based studies investigating associations between psychiatric disorders and dementia (PROSPERO registration: CRD42020209638). We conducted narrative synthesis, and random-effects meta-analyses to obtain pooled estimates. We used meta-regression and stratified analyses to examine variation by sex, age-at-onset and follow-up time.

Results</

SUBMITTER: Stafford J 

PROVIDER: S-EPMC9325434 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature