Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.

ABSTRACT: Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related genetic mouse models (Arid1b^(+/-) , Chd8^(+/-) , 16p11.2 (deletion), Sgsh^(+/-) , Sgsh^(-/-) , Shank3 Δexon 4-9^(+/-) , Shank3 Δexon 4-9^(-/-) , Fmr1^(-/-) , Vps13b^(+/-) ), and pooled wild-type littermates (WTs). We measured heart rate (HR), aorta diameter (AoD), thickness and thickening of the left-ventricular (LV) a

SUBMITTER: Assimopoulos S 

PROVIDER: S-EPMC9325472 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature