Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.

ABSTRACT: Investigation of gene-environment interactions (GxE) may provide important insights into the gene regulatory framework in response to environmental factors of relevance for childhood asthma. Over the years, different methodological strategies have been applied, more recently using genome-wide approaches. The best example to date is the major asthma locus on the 17q12-21 chromosome region, viral infections, and airway epithelium processes where recent studies have shed much light on mechanisms in childhood asthma. However, there are challenges with the traditional single variant-single exposure interaction models, as they do not encompass the complexity and cumulative effects of multiple exposures or multiple genetic variants. As such, we need to redefine our traditional GxE thinking, and w

SUBMITTER: Hernandez-Pacheco N 

PROVIDER: S-EPMC9325482 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature