Progression of Type 1 Diabetes: Circulating MicroRNA Expression Profiles Changes from Preclinical to Overt Disease.

ABSTRACT:

Objectives

To evaluate the potential biological involvement of miRNA expression in the immune response and beta cell function in T1D.

Methods

We screened 377 serum miRNAs of 110 subjects divided into four groups: healthy individuals (control group) and patients at different stages of T1D progression, from the initial immunological manifestation presenting islet autoantibodies (AbP group) until partial and strong beta cell damage in the recent (recent T1D group) and long-term T1D, with 2 to 5 years of disease (T1D 2-5y group).

Results

The results revealed 69 differentially expressed miRNAs (DEMs) in relation to controls. Several miRNAs were correlated with islet autoantibodies (IA2A, GADA, and Znt8A), age, and C-peptide levels, mainly from AbP, and recent T1D groups po

SUBMITTER: Santos AS 

PROVIDER: S-EPMC9325579 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature