T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies.

ABSTRACT: The success of chimeric antigen receptor (CAR) T cells in treating B cell malignancies comes at the price of eradicating normal B cells. Even though T cell malignancies are aggressive and treatment options are limited, similar strategies for T cell malignancies are constrained by the severe immune suppression arising from bystander T cell aplasia. Here, we show the selective killing of malignant T cells without affecting normal T cell-mediated immune responses in vitro and in a mouse model of disseminated leukemia. Further, we develop a CAR construct that carries the single chain variable fragment of a subtype-specific antibody against the variable TCR β-chain region. We demonstrate that these anti-Vβ8 CAR-T cells are able to recognize and kill all Vβ8⁺ malignant T cells that ar

SUBMITTER: Li F 

PROVIDER: S-EPMC9325690 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature