Biological features of TcM: A new Trypanosoma cruzi isolate from Argentina classified into TcV lineage.

ABSTRACT: Trypanosoma cruzi, the etiologic agent of Chagas disease (CD) presents a wide genetic and phenotypic diversity that is classified into seven lineages or discrete typing units (DTU: TcI to TcVI and Tcbat). Although isolates and strains that belong to a particular group can share some attributes, such as geographic distribution, others like growth rate, cell tropism, and response to treatment can be highly variable. In addition, studies that test new trypanocidal drugs are frequently conducted on T. cruzi strains maintained for a long time in axenic culture, resulting in changes in parasite virulence and other important features. This work aimed to isolate and characterize a new T. cruzi strain from a chronic Chagas disease patient. The behavior of this isolate was studi

SUBMITTER: Martinez SJ 

PROVIDER: S-EPMC9325899 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature