Chromosomal integration of bla _CTX-M genes in diverse Escherichia coli isolates recovered from river water in Japan.

ABSTRACT: Occurrence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBLEC) in environmental waters is of great concern. However, unlike clinical ESBLEC, their genetic characteristics, in particular the genetic contexts of ESBL genes, are not well understood. In this study, we sequenced and analyzed the genomes of CTX-M-producing E. coli isolates recovered from river water to fully characterize the genetic contexts of bla _CTX-M genes. Among the 14 isolates with completed genomes, bla _CTX-M genes were detected on the chromosome in nine isolates. All but one chromosomal bla _CTX-M genes were associated with ISEcp1 and were carried on different transposition units ranging in size from 2,855 bp to 11,093 bp; t

SUBMITTER: Gomi R 

PROVIDER: S-EPMC9325909 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature