Irisin/FNDC5 influences myogenic markers on skeletal muscle following high and moderate-intensity exercise training in STZ-diabetic rats.

ABSTRACT: In the present study, we investigated the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on irisin and expression of myogenic markers (paired box 7 (Pax7), myogenic differentiation 1 (MyoD), myogenin) in skeletal muscle of diabetic rats. Eighty-four male Wistar rats (6 weeks of age) were randomly divided into seven groups (n = 12): basic control (Co Basic), 8 weeks control (Co 8w), diabetes mellitus (DM), HIIT, DM + HIIT, MICT, and DM + MICT groups. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ). The V˙o2max protocol was characterized by running on a rodent treadmill with moderate intensity (60-70% V˙o2max ), 60 min per session, 5 days/week, for 6 weeks. HIIT consisted of six 3-min runs at a high int

SUBMITTER: Arabzadeh E 

PROVIDER: S-EPMC9325938 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature