Challenges and Opportunities of Therapies Targeting Early Life Immunity for Pediatric HIV Cure.

ABSTRACT: Early initiation of antiretroviral therapy (ART) significantly improves clinical outcomes and reduces mortality of infants/children living with HIV. However, the ability of infected cells to establish latent viral reservoirs shortly after infection and to persist during long-term ART remains a major barrier to cure. In addition, while early ART treatment of infants living with HIV can limit the size of the virus reservoir, it can also blunt HIV-specific immune responses and does not mediate clearance of latently infected viral reservoirs. Thus, adjunctive immune-based therapies that are geared towards limiting the establishment of the virus reservoir and/or mediating the clearance of persistent reservoirs are of interest for their potential to achieve viral remission in the setting of pedi

SUBMITTER: Berendam SJ 

PROVIDER: S-EPMC9325996 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature