Sulfated Fucogalactan From Laminaria Japonica Ameliorates β-Cell Failure by Attenuating Mitochondrial Dysfunction via SIRT1-PGC1-α Signaling Pathway Activation.

ABSTRACT: As mitochondrial metabolism is a major determinant of β-cell insulin secretion, mitochondrial dysfunction underlies β-cell failure and type 2 diabetes mellitus progression. An algal polysaccharide of Laminaria japonica, sulfated fucogalactan (SFG) displays various pharmacological effects in a variety of conditions, including metabolic disease. We investigated the protective effects of SFG against hydrogen peroxide (H₂O₂)-induced β-cell failure in MIN6 cells and islets. SFG significantly promoted the H₂O₂-inhibited proliferation in the cells and ameliorated their senescence, and potentiated β-cell function by regulating β-cell identity and the insulin exocytosis-related genes and proteins in H₂O₂-induced β-cells. SFG a

SUBMITTER: Wu N 

PROVIDER: S-EPMC9326112 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature