High ambient humidity aggravates ammonia-induced respiratory mucosal inflammation by eliciting Th1/Th2 imbalance and NF-κB pathway activation in laying hens.

ABSTRACT: Ammonia (NH₃) is an irritant and harmful gas. Its accumulation in the poultry house poses detrimental effects on the respiratory mucosal system of birds. In this process, the relative humidity of the poultry house also plays an important role in potentiating the adverse effects of NH₃ on the respiratory status of birds, causing severe physiological consequences. In this study, the combined effects of NH₃ and humidity on the respiratory mucosal barrier of laying hens was studied. The gene expression of tight junction proteins, mucin, inflammatory cytokines secreted by Th1/Th2 cells, and proteins related to the Nuclear factor-κB (NF-κB) signaling pathway were detected by qRT-PCR. In addition, the contents of mucin and secretory immunoglobulin A (SIgA) in bron

SUBMITTER: Wang C 

PROVIDER: S-EPMC9326132 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature