Deconvolution of a Large Cohort of Placental Microarray Data Reveals Clinically Distinct Subtypes of Preeclampsia.

ABSTRACT: It has been well established that the dysfunctional placenta plays an important role in the pathogenesis of preeclampsia (PE), a hypertensive disorder in pregnancy. However, it is not well understood how individual cell types in the placenta are involved in placenta dysfunction because of limited single-cell studies of placenta with PE. Given that a high-resolution single-cell atlas in the placenta is now available, deconvolution of publicly available bulk PE transcriptome data may provide us with the opportunity to investigate the contribution of individual placental cell types to PE. Recent benchmark studies on deconvolution have provided suggestions on the strategy of marker gene selection and the choice of methodologies. In this study, we experimented with these suggestions by using re

SUBMITTER: Yao T 

PROVIDER: S-EPMC9326345 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature