Repetitive DNA Sequences in the Human Y Chromosome and Male Infertility.

ABSTRACT: The male-specific Y chromosome, which is well known for its diverse and complex repetitive sequences, has different sizes, genome structures, contents and evolutionary trajectories from other chromosomes and is of great significance for testis development and function. The large number of repetitive sequences and palindrome structure of the Y chromosome play an important role in maintaining the stability of male sex determining genes, although they can also cause non-allelic homologous recombination within the chromosome. Deletion of certain Y chromosome sequences will lead to spermatogenesis disorders and male infertility. And Y chromosome genes are also involved in the occurrence of reproductive system cancers and can increase the susceptibility of other tumors. In addition, the Y chromo

SUBMITTER: Xu Y 

PROVIDER: S-EPMC9326358 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature