Turnover Kinetics of Pancreatic Macrophages in Lean and Obese Diabetic Mice.

ABSTRACT: Pancreatic resident macrophages, a heterogeneous family of cells with distinct origins and phenotypes, are the main myeloid cells in exocrine and endocrine tissues. Adult exocrine F4/80^hi macrophages consist of three different subsets based on the embryonic marker Tim-4 and MHC II expression. Their frequencies shift during aging and obesity with the Tim-4^-MHCII⁺ fraction becoming the predominant subpopulation in the inter acinar stroma. Endocrine resident F4/80^hi macrophages are more homogenous and represent the prevalent leukocyte fraction residing within the islets in both lean and obese mice. We used an adult fate mapping mouse model to characterize turnover kinetics within the pancreatic resident macrophages under normal homeostasis and obese

SUBMITTER: Ma Z 

PROVIDER: S-EPMC9326506 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature