Long Non-Coding RNAs in Cardiac and Pulmonary Fibroblasts and Fibrosis.

ABSTRACT: The cardiopulmonary system delivers oxygen throughout the body via blood circulation. It is an essential part of the body to sustain the lives of organisms. The integral parts of the cardiopulmonary system-the heart and lungs-are constantly exposed to damaging agents (e.g., dust, viruses), and can be greatly affected by injuries caused by dysfunction in tissues (e.g., myocardial infarction). When damaged, mesenchymal cells, such as fibroblasts, are activated to become myofibroblasts to initiate fibrosis as part of a regenerative mechanism. In diseased states, the excess accumulation of extracellular matrices secreted by myofibroblasts results in further dysfunction in the damaged organs. These fibrotic tissues cannot easily be removed. Thus, there is a growing interest in understanding the

SUBMITTER: Ilieva M 

PROVIDER: S-EPMC9326574 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature