Macrophages Loaded with Fe Nanoparticles for Enhanced Photothermal Ablation of Tumors.

ABSTRACT: Magnetic iron nanoparticle-based theranostics agents have attracted much attention due to their good magnetism and biocompatibility. However, efficiently enriching tumors with iron nanoparticles to enhance the treatment effect remains a pressing challenge. Herein, based on the targeting and high phagocytosis of macrophages, an Fe nanoparticle-loaded macrophage delivery system was designed and constructed to efficiently deliver iron nanoparticles to tumors. Hydrophilic Fe@Fe₃O₄ nanoparticles with a core-shell structure were synthesized by pyrolysis and ligand exchange strategy. Subsequently, they were loaded into macrophages (RAW264.7 cells) using a co-incubation method. After loading into RAW264.7, the photothermal performance of Fe@Fe₃O₄ nanopar

SUBMITTER: Yu L 

PROVIDER: S-EPMC9326737 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature