Pyrosequencing and characterization of immune response genes from the American dog tick, Dermacentor variabilis (L.).

ABSTRACT: Ticks continue to be a threat to animal and human health, and new and novel control strategies are needed for ticks and tick-borne pathogens. The characterization of the tick-pathogen interface and the tick immune response to microbial infections is fundamental toward the formulation of new control strategies for ticks and the pathogens they transmit. Our overall hypothesis for this research is that the tick immune system manages the maintenance of pathogens. Therefore, discovery of tick immune response genes may provide targets for novel control strategies directed toward reducing vector competency and pathogen transmission. In these studies, 454 pyrosequencing, a high-throughput genomic sequencing method was used to discover tick genes expressed in response to bacterial and fungal infect

SUBMITTER: Jaworski DC 

PROVIDER: S-EPMC9327058 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature