Binding of Dual-Function Hybridized Metal-Organic Capsules to Enzymes for Cascade Catalysis.

ABSTRACT: The combination of chemo- and biocatalysis for multistep syntheses provides attractive advantages in terms of evolvability, promiscuity, and sustainability striving for desirable catalytic performance. Through the encapsulation of flavin analogues by both NADH and heme mimics codecorated heteroleptic metal-organic capsules, herein, we report a progressive host-guest strategy to imitate cytochrome P450s catalysis for cascade oxidative coupling catalysis. Besides the construction of stable dual-function metal-organic capsules and the modification of cofactor-decorated capsules at the domain of enzymes, this supramolecular strategy involves multistage directional electron flow, affording reactive ferric peroxide species for inducing oxygenation. Under light irradiation, t

SUBMITTER: Cai J 

PROVIDER: S-EPMC9327082 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature