Behavioral manifestations in rodent models of autism spectrum disorder: protocol for a systematic review and network meta-analysis.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with severe social communication, interaction, and sensory processing impairments. Efforts to understand its etiology and pathophysiology are crucial for improving treatment and prevention measures. Preclinical models of ASD are essential for investigating the biological mechanisms and should present translatability potential. We aim to evaluate the consistency of the most commonly used rodent models of ASD in displaying autistic-like behavior through a systematic review and meta-analysis.

Methods

This review will focus on the most frequently used autism models, surveying studies of six genetic (Ube3a, Pten, Nlgn3, Shank3, Mecp2, and Fmr1), three chemically induced (valproic acid (VPA), li

SUBMITTER: Panzenhagen AC 

PROVIDER: S-EPMC9327140 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature