Canary: an automated tool for the conversion of MaCH imputed dosage files to PLINK files.

ABSTRACT:

Background

Previous studies have demonstrated the value of re-analysing publicly available genetics data with recent analytical approaches. Publicly available datasets, such as the Women's Health Initiative (WHI) offered by the database of genotypes and phenotypes (dbGaP), provide a wealthy resource for researchers to perform multiple analyses, including Genome-Wide Association Studies. Often, the genetic information of individuals in these datasets are stored in imputed dosage files output by MaCH; mldose and mlinfo files. In order for researchers to perform GWAS studies with this data, they must first be converted to a file format compatible with their tool of choice e.g., PLINK. Currently, there is no published tool which easily converts the datasets provided in MACH dosage file

SUBMITTER: Bennett AN 

PROVIDER: S-EPMC9327220 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature