Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modelling study.

ABSTRACT:

Background

Gene drives are a genetic engineering method where a suite of genes is inherited at higher than Mendelian rates and has been proposed as a promising new vector control strategy to reinvigorate the fight against malaria in sub-Saharan Africa.

Methods

Using an agent-based model of malaria transmission with vector genetics, the impacts of releasing population-replacement gene drive mosquitoes on malaria transmission are examined and the population replacement gene drive system parameters required to achieve local elimination within a spatially-resolved, seasonal Sahelian setting are quantified. The performance of two different gene drive systems-"classic" and "integral"-are evaluated. Various transmission regimes (low, moderate, and high-corresponding to annual entom

SUBMITTER: Leung S 

PROVIDER: S-EPMC9327287 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature